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For the record, I also get the same message with the Windows client devprev update latest version 20170310-87e0fc5180-win_x86-devprev. And a question: Was there a recent update to the downloadable Windows foldit installer (or a 'hotfix' - that I missed?

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First you need to download the game by using one of these links:

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First you need to download the game by using one of these links: Windows (XP/Vista/7/8): Macintosh (Intel 10.4 or later). Download Foldit Beta. Make your contribution to science. Downloads Edit. Click a link to download the version for your operating system: [Download Windows] it is a standard installation [Download Macintosh OSX] and drag the Foldit folder to your Applications folder.

Windows (XP/Vista/7/8): http://fold.it/portal/download/windows
Macintosh (Intel 10.4 or later): http://fold.it/portal/download/osx
Linux (64-bit only): http://fold.it/portal/download/linux

FOR HELP WITH THE INTRO PUZZLES: http://foldit.wikia.com/wiki/Tutorial_Puzzles
Get familiar with Foldit's goals by reading our about page: http://fold.it/portal/info/about
Review the community rules while the game is downloading here: http://fold.it/portal/guidelines

Once you have downloaded the game successfully:

Double-click on the Foldit icon on your Desktop.

It will start up, saying 'Contacting Server to Check for Updates..'

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You will be presented with a splash screen with the game credits. Click the green start button.

It will say 'Getting News..'

Wait.

Click OK to go past the news if there is any.

You will be presented with a login screen saying 'Please enter your username and password.'

Enter your username and password, then click 'Play Online'

It will say 'Logging in..' and 'Getting Puzzles..'

Wait.

You will then be prompted to start the first Intro Puzzle:

Once you have beaten all the intro levels you can start playing the Science Puzzles, such as the Beginner Puzzles.

If you want to directly go try the Science Puzzles or Contests, click the Menu tab at the bottom and click on 'Puzzle Menu':

This will bring up the puzzle selection screen, with a colored icon for each completed intro puzzle.
Click 'Main Menu' at the bottom:

and this will bring up the Main Menu Screen, with buttons for 'Intro Puzzles', 'Science Puzzles', 'Contests', and 'Achievements':

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THIS POST IS THANKS TO axcho who originally posted it.
He also created this useful FAQ about the rules & goals of Foldit:

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For even more information, be sure to check out the wiki (http://foldit.wikia.com/wiki/FoldIt_Wiki) there is a lot of great info there, tips, tricks, info about structures, as well as videos for an entire biochemistry class if you want to learn more!

There is also a FAQ for Recipes: http://foldit.wikia.com/wiki/101_-_Cookbook

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